Research Supporting Sublingual Immunotherapy
Millions of people across the globe suffer from allergies, asthma, and other related immunologic disease.
Though clinical practice of sublingual immunotherapy in the U.S. dates
back nearly 100 years, sublingual immunotherapy research validating
what was learned clinically has only begun to garner attention in the past few decades.
modern research references for sublingual immunotherapy,
including recent findings through the
Agency for Healthcare Research & Quality (AHRQ),
World Health Organization, and Cochrane Collaboration
studies that specifically address the key tenets of the La Crosse Method™ Protocol
A large number of controlled clinical trials in Europe have shown
the effectiveness of sublingual immunotherapy in the treatment
of allergic rhinitis and asthma for single antigens.
More studies are underway in the U.S. and globally,
including studies that explore food allergies.
Additional research has shed light on the mechanisms behind
sublingual immunotherapy, notably the unique role
dendritic cells under the tongue play in building allergen tolerance.